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Top 25 BioTech startups Startups transforming our lives one step at a time

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It’s fair to say that BioTech has probably never been as much in the public eye as it has been over the past two years.

And while everyone has now heard of household names, such as Pfizer, AstraZeneca, Moderna and others, there are many other BioTech startups doing amazing work and research, that may all be just on the cusp of the world’s next major bio development.

To give just a small taste of what some of these incredible companies are doing, here are some of the top 25 BioTech startups currently making a name for themselves.


Arctoris

Arctoris is a tech-enabled platform company in biotechnology, combining robotics and data science to accelerate drug discovery. Arctoris’ unique drug discovery platform uses advanced robotics, data science and an experienced team of BioTech and pharma veterans. Their team is pursuing several drug discovery programs in oncology and neuro.

Arctoris

Founded:

2016 – Oxford, UK

Martin-Immanuel Bittner, Thomas Fleming

Total funding: $10m

Web: https://www.arctoris.com/


Autolus

Autolus is a London based bio-technology startup specialising in T-cell programming. Autolus’ programme of development in T-cell therapies is set to be a breakthrough approach in targeting haematological cancers and solid tumours. Autolus also manufactures new technology.

Autolus

Founded:

2014 – London, UK

Martin Pule

Total funding: $631.7m

Web: https://www.autolus.com/


Bit.bio

Bit.bio specialises in coding and biology that determine the identity of every human cell. At present, Bit.bio is developing a scalable technology platform capable of producing consistent batches of every human cell. If successful, this will enable research and drug discovery to efficiently work with cells that are affected by human disease. This will also provide the basis for a new generation of cell and tissue therapies.

Bit.bio

Founded:

2016 – Cambridge, UK

Florian Schuster, Mark Kotter

Total funding: $145m

Web: https://bit.bio/


Carbios

Carbios is a BioTech company focusing on chemical engineering. Specifically, Carbios focuses on discovering and developing enzymatic bioprocesses applied to plastic and textile polymers. Carbios creates a new generation of fully biodegradable plastics with a controlled lifespan to limit plastic waste.

Carbios

Founded:

2011 – Saint-beauzire, Auvergne, France

Jean-Claude Lumaret

Total funding: €17.8m

Web: https://www.carbios.com/


Clade Therapeutics

Clade Therapeutics is a biotechnology company that discovers and delivers medicines to improve the lives of patients. The startup focuses on next-general cell therapies.

Clade Therapeutics

Founded:

2020 – Cambridge, Massachusetts, United States

Chad Cowan, Jim Glasheen, Leandro Vetcher

Total funding: $87m

Web: https://cladetx.com/


Compass Pathways

Compass Pathways is a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health. Compass Pathways is developing psychedelic treatments against clinical depression based on psilocybin, the main ingredient found in magic mushrooms which are effective in treating depression.

COMPASS Pathways

Founded:

2016 – Altrincham, Cheshire, UK

Ekaterina Malievskaia, George Goldsmith, Lars Christian Wilde

Total funding: $116.2m

Web: https://www.compasspathways.com/


DNA Script

DNA Script is a disruptive BioTech company, specialising in DNA synthesis. The team at DNA Script are currently harnessing biology to accelerate breakthroughs in life science and human health. Their revolutionary enzymatic technology powers the world’s first benchtop DNA printer, SYNTAX.

DNA Script

Founded:

2016 – Le Kremlin-bicêtre, Ile-de-France, France

Sylvain Gariel, Thomas Ybert, Xavier Godron

Total funding: $479.8m

Web: https://www.dnascript.com/


EnteroBiotix

EnteroBiotix is a BioTech company that is developing ground-breaking medicinal products intended to restore health and prevent bacterial infections. EnteroBiotix is developing and advancing novel microbiome modulating drugs composed of bacterial communities derived directly from the human gastrointestinal tract associated with imbalances of bacteria in the human gut.

EnteroBiotix

Founded:

2017 – Edinburgh, Scotland, UK

James McIlroy

Total funding: $18m

Web: https://www.enterobiotix.com/


eTheRNA

eTheRNA develops immunotherapies that target the fundamental role of dendritic cells in the human immune system. eTheRNA immunotherapies aims to help patients to overcome certain cancers and infectious diseases through their novel pathways to immunotherapy; targeting the fundamental role of dendritic cells in the immune system.

eTheRNA immunotherapies

Founded:

2013 – Jette, Belgium

Kris Thielemans

Total funding: $73m

Web: https://www.etherna.be/


ExoTherapeutics

ExoTherapeutics is a BioTech startup specialising in small molecule drug discovery and development. ExoTherapeutics team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics

Founded:

2018 – Cambridge, Massachusetts, United States

David R. Liu

Total funding: $103m

Web: https://www.eco-therapeutics.com/


Freeline

Freeline Therapeutics is a biotechnology company whose focus is the development of liver-directed gene therapies for a range of diseases. Their mission is to transform the lives of patients suffering from debilitating hereditary diseases. Freeline has clinical programs in Hemophilia B and Fabry disease, and additional preclinical programs in Gaucher disease and Hemophilia A.

Freeline

Founded:

2014 – Stevenage, Hertfordshire, UK

Amit Nathwani, Markus Hörer

Total funding: $276m

Web: https://www.freeline.life/


GammaDelta Therapeutics

GammaDelta Therapeutics is a BioTech startup company developing the potential of gamma delta (γδ) cells to improve immunotherapy treatment of cancer and other serious diseases. GammaDelta plans to use unique properties of tissue-resident γδ T cells to leverage effective immunotherapy.

GammaDelta Therapeutics

Founded:

2016 – London, UK

Adrian Hayday

Total funding: $100m

Web: https://www.gammadeltatx.com/


Gedea Biotech

Gedea Biotech develops an antibiotic-free, safe and effective treatment of vaginal fungal infections. Vaginal yeast infections are a common infection that affects the majority of women at least once in their life. Gedea Biotech’s substance, GA101, is a natural substance that treats yeast infections by lowering the pH as well as providing physical barrier protection.

Gedea Biotech

Founded:

2015 – Lund, Skane Lan, Sweden

Helena Strevens, Olov Sterner, Sophie Manner, Ulf Ellervik

Total funding: $1.4m

Web: https://www.gedeabiotech.com/


Kuur Therapeutics

Kuur Therapeutics is a BioTech startup that is dedicated to transforming the lives of cancer patients. Kuur is developing off-the-shelf engineered CAR-NKT cell therapies. Their radical approach combines the highly differentiated, natural biology of a specific subset of cytotoxic T cells, called natural killer T cells (NKT cells) and innovative CAR construct engineering.

Kuur Therapeutics

Founded:

2005 – London, UK

Gregg Sando

Total funding: $191.8m

Web: https://www.kuurtx.com/


Macomics

Macomics is a BioTech startup specialising in immuno-oncology. Macomics focuses on the development of novel, first-in-class immunotherapies designed to modulate macrophages, to increase the body’s immune defence against tumours.

Macomics

Founded:

2020 – Edinburgh, UK

Coral Ries, Jeffrey Pollard, Luca Cassetta, Stephen Myatt

Total funding: $7.4m

Web: https://www.macomics.com/


Oryzon Genomics

Oryzon Genomics is a clinical‐stage biopharmaceutical company leveraging epigenetics to develop therapies in diseases. The European BioTech is creating epigenetic drugs for the treatment of neurological diseases and cancer.

Oryzon Genomics

Founded:

2000 – Madrid, Spain

Carlos Buesa, Tamara Maes

Total funding: $139.9m

Web: https://www.oryzon.com/


Phytoform Labs

Phytoform Labs is a biotechnology company whose specialism is resilient and sustainable crops. The biotechnology company’s goal is to help breeders to cut down plant breeding times from a span of decades to years thanks to novel gene-editing technologies. Predictably evolving plants will maximise yields for breeders and improve the economics of breeding for customers.

Phytoform Labs

Founded:

2017 – Salisbury, UK

Nicolas Kral, William Pelton

Total funding: $5.8m

Web: https://www.phytoformlabs.com/


ReViral

ReViral is a biotechnology startup specialising in the development of antiviral therapies. ReViral hopes to expand the antiviral market with its development of novel first-in-class compounds.

ReViral has pioneered a fusion inhibitor of RSV; a highly potent, novel small molecule and is being developed to treat RSV in patients with severe disease including neonates.

ReViral

Founded:

2011 – Stevenage, UK

Ken Powell, Neil Mathews, Stuart Cockerill

Total funding: $121m

Web: https://www.reviral.co.uk/


Scorpion Therapeutics

Scorpion Therapeutics is a biotech company that broadens the reach and impact of precision medicine in the field of oncology. The company is integrating cutting-edge technologies across target discovery, medicinal chemistry, and translational medicine.

Scorpion Therapeutics

Founded:

2020 – Boston, Massachusetts, United States

Gaddy Getz, Gary Glick, Keith Flaherty, Liron Bar-Peled

Total funding: $270m

Web: https://www.scorpiontx.com/


Solar Foods

Solar Foods is a pioneer in the alternative food space within biotechnology. The startup develops a novel nutrient-rich protein using only air and electricity as the main resources. This is a ground-breaking approach to food production, as it is not dependent on agriculture, the weather, or the climate.

Solar Foods

Founded:

2017 – Helsinki, Finland

Juha-Pekka Pitkänen, Pasi Vainikka

Total funding: $42m

Web: https://www.solarfoods.fi/


Transine Therapeutics

Transine Therapeutics is a developer of a biotech platform enhancing therapeutics for the treatment of disease. The startup’s pioneering technology is expected to offer a unique mechanism for currently hard-to-treat diseases.

Transine Therapeutics

Founded:

2018 – Cambridge, UK

Piero Carninci, Stefano Gustincich

Total funding: $12.9m

Web: https://www.transinetx.com/


TreeFrog Therapeutics

TreeFrog Therapeutics is a biotech startup, specialising in stem cell production. This will enable millions of patients to access the medical revolution of cell therapies. The company aims to secure cell production and quality, fasten clinical development and facilitate market access.

TreeFrog Therapeutics

Founded:

2018 – Bordeaux, Aquitaine, France

Erwan Bezard, Jean-Luc Treillou, Kevin Alessandri, Laurent Cognet, Maxime Feyeux, Pierre Nassoy

Total funding: $86.9m

Web: https://www.treefrog.fr/


Valo Therapeutics

Valo Therapeutics is a biotech company, specialising in immuno-oncology therapy. Valo Therapeutics is developing tumour antigen-coated oncolytic viruses as therapeutic vaccines.

Valo Therapeutics

Founded:

2018 – Helsinki, Finland

Vincenzo Cerullo

Total funding: $9.2m

Web: https://www.valotx.com/


Verve Therapeutics

Verve Therapeutics is a genetic medicines company creating a novel methodology for the care of cardiovascular disease, transforming treatment from chronic management to single-course gene editing medicines. Verve’s goal is to discover and develop therapies that safely edit the genomes of adults to confer protection against coronary diseases.

Verve Therapeutics

Founded:

2018 – Cambridge, Massachusetts, United States

Anthony Philippakis, Barry Ticho, Burt Adelman, Issi Rozen, J. Keith Joung, Kiran Musunuru, Sekar Kathiresan

Total funding: $215.5m

Web: https://www.vervetx.com/


Virion Biotherapeutics

Virion Biotherapeutics is a startup that is developing biological antivirals targeted towards respiratory viral infections, including influenza and RSV. These novel treatment options will enable doctors to get a broad-spectrum therapy for respiratory viral infections, which could simplify and accelerate treatment by negating the need for differential diagnosis.

Virion Biotherapeutics

Founded:

2017 – Zürich, Zurich, Switzerland

Vanessa King

Total funding: $21.2m

Web: https://www.virionbiotx.com/


This list includes startups that are striving to change all our lives for the better.

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